Neuraminidase Content of Influenza Vaccines and Neuraminidase Antibody Responses after Vaccination of Immunologically Primed and Unprimed Populations
Identifieur interne : 002A60 ( Main/Exploration ); précédent : 002A59; suivant : 002A61Neuraminidase Content of Influenza Vaccines and Neuraminidase Antibody Responses after Vaccination of Immunologically Primed and Unprimed Populations
Auteurs : Alan P. Kendal [Géorgie (pays), États-Unis] ; Gary R. Noble [Géorgie (pays)] ; Walter R. Dowdle [Géorgie (pays)]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1977.
Abstract
Vaccines prepared with influenza A/swine/1976/37-like virus contained neuraminidase activity comparable to that of H3N2 vaccines, whereas little neuraminidase activity could be detected in influenza A/New Jersey /76 vaccines. In single-dose vaccine studies, Ajswinejl976j37.like split-virus vaccine induced antibody to neuraminidase (NAAb) in about 20% of children younger than 18 years, and this NAAb response was better than or equal to the antibody response to the vaccine's hemagglutinin (HAAb). In immunologically primed adults, the NAAb response to a single dose of HswlNl or H3N2 vaccine was 38%–54%, but this value was about 1.7-fold lower than that for HAAb response. Children six to 17 years old given two doses of Ajswinejl976j37-like vaccine had an overall 70% NAAb response, whereas children of similar age had an overall 30%–48% NAAb response to two doses of AjVictoria/3/75 (H3N2) virus. The findings support a hypothesis that the NAAb response to influenza vaccines can be suppressed if subjects receiving the vaccine are immunologically primed to its hemagglutinin component. NAAb responses in the absence of HAAb responses occur in only about 5% of vaccinated persons who are immunologically primed to both the hemagglutinin and neuraminidase of the vaccine.
Url:
DOI: 10.1093/infdis/136.Supplement_3.S415
Affiliations:
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Neuraminidase Content of Influenza Vaccines and Neuraminidase Antibody Responses after Vaccination of Immunologically Primed and Unprimed Populations</title><author><name sortKey="Kendal, Alan P" sort="Kendal, Alan P" uniqKey="Kendal A" first="Alan P." last="Kendal">Alan P. Kendal</name></author><author><name sortKey="Noble, Gary R" sort="Noble, Gary R" uniqKey="Noble G" first="Gary R." last="Noble">Gary R. Noble</name></author><author><name sortKey="Dowdle, Walter R" sort="Dowdle, Walter R" uniqKey="Dowdle W" first="Walter R." last="Dowdle">Walter R. Dowdle</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:609EF451D68B6274DA45511A2D185AC96FAF9D5C</idno><date when="1977" year="1977">1977</date><idno type="doi">10.1093/infdis/136.Supplement_3.S415</idno><idno type="url">https://api.istex.fr/ark:/67375/HXZ-F8F77DF8-J/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000C93</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000C93</idno><idno type="wicri:Area/Istex/Curation">000C93</idno><idno type="wicri:Area/Istex/Checkpoint">001638</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001638</idno><idno type="wicri:doubleKey">0022-1899:1977:Kendal A:neuraminidase:content:of</idno><idno type="wicri:Area/Main/Merge">002C21</idno><idno type="wicri:Area/Main/Curation">002A60</idno><idno type="wicri:Area/Main/Exploration">002A60</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Neuraminidase Content of Influenza Vaccines and Neuraminidase Antibody Responses after Vaccination of Immunologically Primed and Unprimed Populations</title><author><name sortKey="Kendal, Alan P" sort="Kendal, Alan P" uniqKey="Kendal A" first="Alan P." last="Kendal">Alan P. Kendal</name><affiliation wicri:level="1"><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>World Health Organization Collaborating Center for Influenza, Respiratory Virology Branch, Virology Division, Bureau of Laboratories, Center for Disease Control, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Please address requests for reprints to Dr. Alan P. Kendal, Respiratory Virology Branch, 7-112, Center fur Disease Control, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Noble, Gary R" sort="Noble, Gary R" uniqKey="Noble G" first="Gary R." last="Noble">Gary R. Noble</name><affiliation wicri:level="1"><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>World Health Organization Collaborating Center for Influenza, Respiratory Virology Branch, Virology Division, Bureau of Laboratories, Center for Disease Control, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Dowdle, Walter R" sort="Dowdle, Walter R" uniqKey="Dowdle W" first="Walter R." last="Dowdle">Walter R. Dowdle</name><affiliation wicri:level="1"><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>World Health Organization Collaborating Center for Influenza, Respiratory Virology Branch, Virology Division, Bureau of Laboratories, Center for Disease Control, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1977-12">1977</date><biblScope unit="vol">136</biblScope><biblScope unit="issue">Supplemet_3</biblScope><biblScope unit="page" from="S415">S415</biblScope><biblScope unit="page" to="S424">S424</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Vaccines prepared with influenza A/swine/1976/37-like virus contained neuraminidase activity comparable to that of H3N2 vaccines, whereas little neuraminidase activity could be detected in influenza A/New Jersey /76 vaccines. In single-dose vaccine studies, Ajswinejl976j37.like split-virus vaccine induced antibody to neuraminidase (NAAb) in about 20% of children younger than 18 years, and this NAAb response was better than or equal to the antibody response to the vaccine's hemagglutinin (HAAb). In immunologically primed adults, the NAAb response to a single dose of HswlNl or H3N2 vaccine was 38%–54%, but this value was about 1.7-fold lower than that for HAAb response. Children six to 17 years old given two doses of Ajswinejl976j37-like vaccine had an overall 70% NAAb response, whereas children of similar age had an overall 30%–48% NAAb response to two doses of AjVictoria/3/75 (H3N2) virus. The findings support a hypothesis that the NAAb response to influenza vaccines can be suppressed if subjects receiving the vaccine are immunologically primed to its hemagglutinin component. NAAb responses in the absence of HAAb responses occur in only about 5% of vaccinated persons who are immunologically primed to both the hemagglutinin and neuraminidase of the vaccine.</div></front></TEI><affiliations><list><country><li>Géorgie (pays)</li><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li></region></list><tree><country name="Géorgie (pays)"><noRegion><name sortKey="Kendal, Alan P" sort="Kendal, Alan P" uniqKey="Kendal A" first="Alan P." last="Kendal">Alan P. Kendal</name></noRegion><name sortKey="Dowdle, Walter R" sort="Dowdle, Walter R" uniqKey="Dowdle W" first="Walter R." last="Dowdle">Walter R. Dowdle</name><name sortKey="Noble, Gary R" sort="Noble, Gary R" uniqKey="Noble G" first="Gary R." last="Noble">Gary R. Noble</name></country><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Kendal, Alan P" sort="Kendal, Alan P" uniqKey="Kendal A" first="Alan P." last="Kendal">Alan P. Kendal</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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